THAP1

Across TCGA cell cohorts, THAP1 mutation is significantly associated with the mutation status of many other genes, with 52 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible THAP1-associated genes across cancer lineages are ZMAT5, USP31, and IL21R. Each is linked with THAP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both THAP1-to-partner and partner-to-THAP1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ZMAT5 grouped by THAP1-low versus THAP1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THAP1→partner) and Y-score (partner→THAP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	ZMAT5 →	+6.321	+6.321	.001	.001	1	1
BLOOD_Leukemia	USP31 →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	IL21R →	+4.736	+5.560	.003	.003	1	1
BLOOD_Leukemia	TUSC3 →	+4.736	+5.560	.003	.003	1	1
BLOOD_Leukemia	UPK1A →	+4.321	+5.285	.005	.005	1	1
BLOOD_Leukemia	GRB10 →	+4.000	+5.050	.008	.008	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

ZMAT5 by THAP1 expression — BLOOD_Leukemia

Explore this box plot interactively →