STIP1 homology and U-box containing protein 1Genealiases: CHIP · HSPABP2 · NY-CO-7 · SCA48 · SCAR16 · SDCCAG7
Q-omics provides the consensus-scored STUB1 profile across patient tissues and cancer cell-line models. STUB1 expression is associated with patient survival in 26 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, STUB1 is differentially expressed in 9, with the highest sampling consensus in COAD. Additionally, STUB1 protein abundance shows 24,211 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight KIRC, COAD, and BRCA as cancer lineages where STUB1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for STUB1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes STUB1 survival associations across molecular data types. STUB1 RNA expression shows survival associations in the most cancer types (26), followed by mutation status (3) and mass-spec protein abundance (9). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible STUB1 RNA expression–survival associations across cancer types. High STUB1 expression shows unfavorable associations in KIRP, LIHC, SCLC and BRCA, but favorable associations in KIRC and LGG. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for STUB1 RNA expression.
This table summarizes STUB1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 9, while mass-spec protein shows differences in 6. The strongest signals are observed in COAD for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for STUB1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. STUB1 shows lower tumor expression in UCEC and higher tumor expression in COAD, LIHC, KIRP, HNSC and CHOL. The COAD box plot shows higher STUB1 RNA expression in tumor versus normal tissue (log2 FC = +0.688, t-test p < 0.001).
This table shows molecular features associated with STUB1 in patient tissues and cancer cell lines. In patient samples, STUB1 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, STUB1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in OESOPHAGUS and UPPER_AERODIGESTIVE_TRACT.
