STUB1

Across TCGA patient cohorts, STUB1 mutation is significantly associated with the RNA expression of many other genes, with 99 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible STUB1-associated genes across cancer lineages are RNU6-492P, RNY3P11, and RNA5SP131. Each is linked with STUB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both STUB1-to-partner and partner-to-STUB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-492P grouped by STUB1-low versus STUB1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (STUB1→partner) and Y-score (partner→STUB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-492P →	+0.478	+7.954	<.001	.008	3	2
UCEC	RNY3P11 →	+0.292	+3.899	.001	<.001	3	2
UCEC	RNA5SP131 →	+0.467	+3.329	<.001	.005	3	2
UCEC	HMGB1P45 →	+0.179	+2.606	.003	.006	3	2
COAD	TUBB1P1 →	+0.022	+4.136	<.001	.008	3	2
BLCA	UBL5P1 →	+0.215	+5.444	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 99 associations by consensus.

RNU6-492P by STUB1 expression — HNSC

Explore this box plot interactively →