SPARC (osteonectin), cwcv and kazal like domains proteoglycan 1Genealiases: SPOCK · TESTICAN · TIC1
Q-omics provides the consensus-scored SPOCK1 profile across patient tissues and cancer cell-line models. SPOCK1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, SPOCK1 is differentially expressed in 13, with the highest sampling consensus in HNSC. Additionally, SPOCK1 RNA expression shows 20,765 significant protein co-abundance associations, with the highest sampling consensus in BRCA. Together, these results highlight UVM, HNSC, and BRCA as cancer lineages where SPOCK1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SPOCK1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SPOCK1 survival associations across molecular data types. SPOCK1 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (3) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SPOCK1 RNA expression–survival associations across cancer types. High SPOCK1 expression shows unfavorable associations in UVM, HNSC, LUAD, STAD and KIRP, but favorable associations in LGG. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for SPOCK1 RNA expression.
This table summarizes SPOCK1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 1. The strongest signals are observed in HNSC for RNA and LSCC for protein.
This table ranks reproducible tumor–normal expression differences for SPOCK1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SPOCK1 shows lower tumor expression in KICH and higher tumor expression in HNSC, LUAD, THCA, LUSC and LIHC. The HNSC box plot shows higher SPOCK1 RNA expression in tumor versus normal tissue (log2 FC = +1.778, t-test p < 0.001).
This table shows molecular features associated with SPOCK1 in patient tissues and cancer cell lines. In patient samples, SPOCK1 shows the broadest associations at the RNA and protein expression levels, with BRCA recurring as the lineage with the largest associated feature set. In cancer cell lines, SPOCK1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and BONE.
