SPOCK1

Across TCGA cell cohorts, SPOCK1 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SPOCK1-associated genes across cancer lineages are C6orf118, PRAMEF20, and GSG1L2. Each is linked with SPOCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK1-to-partner and partner-to-SPOCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by SPOCK1-low versus SPOCK1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK1→partner) and Y-score (partner→SPOCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.175	+3.793	<.001	.007	3	1
LARGE_INTESTINE	PRAMEF20 →	+0.012	+4.437	<.001	.004	3	1
LARGE_INTESTINE	GSG1L2 →	+0.016	+4.437	<.001	.004	3	1
LUNG_NSCLC_LUAD	MEIKIN →	+0.155	+4.887	<.001	.009	3	1
SKIN	AQP2 →	+0.029	+3.938	.003	.005	3	1
SKIN	PTGDR →	+0.012	+3.930	.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

C6orf118 by SPOCK1 expression — LARGE_INTESTINE

Explore this box plot interactively →