SPOCK1

Across TCGA cell cohorts, SPOCK1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,417 significant associations in total. BONE shows the largest number of these associations.

The most reproducible SPOCK1-associated GO terms across cancer lineages are Negative regulation of plasminogen activation, Regulation of cell-substrate adhesion, and Collagen fibril organization. Each is linked with SPOCK1 in more than 13 cancer types. Because this analysis shows association rather than direction, both SPOCK1-to-partner and partner-to-SPOCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of plasminogen activation grouped by SPOCK1-low versus SPOCK1-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK1→partner) and Y-score (partner→SPOCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Negative regulation of plasminogen activation →	+1.440	+4.486	<.001	<.001	3	14
BONE	Regulation of cell-substrate adhesion →	+0.111	+3.789	<.001	<.001	3	14
BONE	Collagen fibril organization →	+0.325	+3.751	<.001	<.001	3	14
BONE	Wound healing →	+0.127	+3.841	<.001	<.001	3	14
BONE	Regulation of stress fiber assembly →	+0.104	+3.098	<.001	<.001	3	14
BONE	Positive regulation of extracellular matrix organization →	+0.164	+4.324	<.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,417 associations by consensus.

Negative regulation of plasminogen activation by SPOCK1 expression — BONE

Explore this box plot interactively →