SPOCK1

Across TCGA patient cohorts, SPOCK1 mutation is significantly associated with the RNA expression of many other genes, with 3,612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOCK1-associated genes across cancer lineages are RN7SKP128, RPS2P39, and RN7SKP14. Each is linked with SPOCK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SPOCK1-to-partner and partner-to-SPOCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SKP128 grouped by SPOCK1-low versus SPOCK1-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK1→partner) and Y-score (partner→SPOCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RN7SKP128 →	+0.124	+4.505	.001	.009	3	3
LIHC	RPS2P39 →	+0.052	+4.878	<.001	.005	3	3
LIHC	RN7SKP14 →	+0.254	+4.544	<.001	.009	3	3
SKCM	MCM5 →	+0.708	+3.497	<.001	.002	3	3
UCEC	WDR62 →	+0.731	+2.273	<.001	<.001	3	3
UCEC	INCENP →	+0.696	+2.446	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,612 associations by consensus.

RN7SKP128 by SPOCK1 expression — HNSC

Explore this box plot interactively →