SPOCK1

Across TCGA patient cohorts, SPOCK1 mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SPOCK1-associated genes across cancer lineages are JNK_pT183_Y185, FoxM1, and FOXO3a_pS318_S321. Each is linked with SPOCK1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SPOCK1-to-partner and partner-to-SPOCK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by SPOCK1-low versus SPOCK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SPOCK1→partner) and Y-score (partner→SPOCK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.178	-2.074	.005	.005	3	2
UCEC	FoxM1 →	+0.254	+1.678	.010	.023	3	2
UCEC	FOXO3a_pS318_S321 →	-0.122	-2.212	.010	.010	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.398	+1.884	.041	.030	3	2
UCEC	JNK2 →	+0.251	+1.678	<.001	.023	3	2
UCEC	TFRC →	+0.646	+3.584	.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

JNK_pT183_Y185 by SPOCK1 expression — UCEC

Explore this box plot interactively →