solute carrier family 24 member 1Genealiases: CSNB1D · HsT17412 · NCKX · NCKX1 · RODX
Q-omics provides the consensus-scored SLC24A1 profile across patient tissues and cancer cell-line models. SLC24A1 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in UCEC. Among the 18 cancer types available for tumor–normal comparison, SLC24A1 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, SLC24A1 RNA expression shows 21,019 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight UCEC, THCA, and THYM as cancer lineages where SLC24A1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SLC24A1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SLC24A1 survival associations across molecular data types. SLC24A1 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (5) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SLC24A1 RNA expression–survival associations across cancer types. High SLC24A1 expression shows unfavorable associations in LGG, LUSC and BLCA, but favorable associations in UCEC, KIRC and UCS. The UCEC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify UCEC as the clearest survival context for SLC24A1 RNA expression.
This table summarizes SLC24A1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 1. The strongest signals are observed in THCA for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for SLC24A1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SLC24A1 shows lower tumor expression in THCA and KIRC and higher tumor expression in HNSC, COAD, CHOL and STAD. The THCA box plot shows higher SLC24A1 RNA expression in normal versus tumor tissue (log2 FC = −0.706, t-test p < 0.001).
This table shows molecular features associated with SLC24A1 in patient tissues and cancer cell lines. In patient samples, SLC24A1 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, SLC24A1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SOFT_TISSUE, while CRISPR and shRNA rows add functional-dependency signals in LUNG_SCLC and UPPER_AERODIGESTIVE_TRACT.
