SLC24A1

Across TCGA pan-cancer cohorts, SLC24A1 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of SLC24A1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where SLC24A1 RNA is repressed in tumor relative to normal tissue. In most cancer types SLC24A1 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

THCA, HNSC, and COAD are the cancer types where SLC24A1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in SLC24A1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	II,III,IV	−0.706	<.001	9	view →
HNSC	All	All	+0.401	<.001	9	view →
COAD	All	All	+0.408	<.001	8	view →
KIRC	All	II,III,IV	−0.379	.001	6	view →
CHOL	All	II,III,IV	+1.610	<.001	5	view →
STAD	Male	II,III,IV	+0.923	<.001	5	view →
LIHC	All	All	+0.372	<.001	5	view →
UCEC	All	All	−0.847	<.001	2	view →
KIRP	Female	II,III,IV	+0.633	.038	2	view →
LUSC	Male	All	−0.201	.037	1	view →
BRCA	Female	All	−0.170	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

SLC24A1–THCA

Open the THCA breakdown →