Q-omics provides the consensus-scored SF1 profile across patient tissues and cancer cell-line models. SF1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in ACC. Among the 18 cancer types available for tumor–normal comparison, SF1 is differentially expressed in 12, with the highest sampling consensus in HNSC. Additionally, SF1 protein abundance shows 22,978 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight ACC, HNSC, and LSCC as cancer lineages where SF1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SF1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SF1 survival associations across molecular data types. SF1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (9) and mass-spec protein abundance (4). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SF1 RNA expression–survival associations across cancer types. High SF1 expression shows unfavorable associations in ACC, LIHC and KICH, but favorable associations in UCS, KIRC and BRCA. The ACC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify ACC as the clearest survival context for SF1 RNA expression.
This table summarizes SF1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 12, while mass-spec protein shows differences in 5. The strongest signals are observed in THCA for RNA and LUAD for protein.
This table ranks reproducible tumor–normal expression differences for SF1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SF1 shows lower tumor expression in THCA and KICH and higher tumor expression in HNSC, LIHC, COAD and CHOL. The HNSC box plot shows higher SF1 RNA expression in tumor versus normal tissue (log2 FC = +0.695, t-test p < 0.001).
This table shows molecular features associated with SF1 in patient tissues and cancer cell lines. In patient samples, SF1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SF1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in OVARY, while CRISPR and shRNA rows add functional-dependency signals in SKIN and BLOOD_Leukemia.
