SF1

Across TCGA cell cohorts, SF1 mutation is significantly associated with the RNA expression of many other genes, with 631 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SF1-associated genes across cancer lineages are TMEM207, OR2L8, and OR14A16. Each is linked with SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF1-to-partner and partner-to-SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TMEM207 grouped by SF1-low versus SF1-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF1→partner) and Y-score (partner→SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	TMEM207 →	+0.622	+4.523	<.001	.004	3	2
OVARY	OR2L8 →	+0.037	+3.865	<.001	.001	3	2
BLOOD_Lymphoma	OR14A16 →	+0.017	+4.643	<.001	.005	3	1
BLOOD_Leukemia	P2RX3 →	+0.050	+3.551	<.001	.008	3	1
BLOOD_Leukemia	BHLHE23 →	+1.138	+3.691	.001	.005	3	1
BLOOD_Leukemia	KRT71 →	+0.034	+3.922	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 631 associations by consensus.

TMEM207 by SF1 expression — BLOOD_Lymphoma

Explore this box plot interactively →