SF1

Across TCGA patient cohorts, SF1 mutation is significantly associated with the total protein of many other genes, with 17 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SF1-associated genes across cancer lineages are Caspase-7-cleavedD198, MSH2, and Notch1. Each is linked with SF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SF1-to-partner and partner-to-SF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by SF1-low versus SF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SF1→partner) and Y-score (partner→SF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.999	+3.341	<.001	.005	3	2
UCEC	MSH2 →	-0.379	-3.295	<.001	.009	3	2
UCEC	Notch1 →	+0.172	+2.183	.003	.033	3	2
UCEC	ATM →	-0.483	-2.222	.012	.011	3	2
BLCA	Annexin_VII →	-0.168	-3.000	.034	.036	3	1
COAD	YB-1 →	-0.502	-3.000	.010	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

Caspase-7-cleavedD198 by SF1 expression — UCEC

Explore this box plot interactively →