signal peptide, CUB domain and EGF like domain containing 1Genealiases: []
Q-omics provides the consensus-scored SCUBE1 profile across patient tissues and cancer cell-line models. SCUBE1 expression is associated with patient survival in 22 of 34 cancer types, with the highest sampling consensus in CESC. Among the 18 cancer types available for tumor–normal comparison, SCUBE1 is differentially expressed in 13, with the highest sampling consensus in KIRP. Additionally, SCUBE1 RNA expression shows 16,237 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight CESC, KIRP, and TGCT as cancer lineages where SCUBE1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SCUBE1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SCUBE1 survival associations across molecular data types. SCUBE1 RNA expression shows survival associations in the most cancer types (22), followed by mutation status (6) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SCUBE1 RNA expression–survival associations across cancer types. High SCUBE1 expression shows unfavorable associations in ACC, UCS and CHOL, but favorable associations in CESC, BLCA and HNSC. The CESC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify CESC as the clearest survival context for SCUBE1 RNA expression.
This table summarizes SCUBE1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 3. The strongest signals are observed in KIRP for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SCUBE1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SCUBE1 shows lower tumor expression in KIRP, COAD, LUSC, LUAD and KIRC and higher tumor expression in LIHC. The KIRP box plot shows higher SCUBE1 RNA expression in normal versus tumor tissue (log2 FC = −1.498, t-test p < 0.001).
This table shows molecular features associated with SCUBE1 in patient tissues and cancer cell lines. In patient samples, SCUBE1 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, SCUBE1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
