SCUBE1

Across TCGA patient cohorts, SCUBE1 mutation is significantly associated with the RNA expression of many other genes, with 3,465 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCUBE1-associated genes across cancer lineages are MRPL37, ICMT, and SLC66A2. Each is linked with SCUBE1 in more than 3 cancer types. Because this analysis shows association rather than direction, both SCUBE1-to-partner and partner-to-SCUBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL37 grouped by SCUBE1-low versus SCUBE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE1→partner) and Y-score (partner→SCUBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL37 →	+0.340	+1.895	.002	.001	3	4
UCEC	ICMT →	+0.301	+1.890	.004	.001	3	4
STAD	SLC66A2 →	+0.437	+3.236	.005	.008	3	4
STAD	RASSF1 →	+0.513	+2.857	<.001	.001	3	4
STAD	CHCHD4 →	+0.450	+2.609	.001	.005	3	4
LIHC	RN7SL627P →	+0.099	+5.676	<.001	.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,465 associations by consensus.

MRPL37 by SCUBE1 expression — UCEC

Explore this box plot interactively →