SCUBE1

Across TCGA cell cohorts, SCUBE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,689 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible SCUBE1-associated GO terms across cancer lineages are Regulation of organelle assembly, Chaperone-mediated autophagy, and Positive regulation of tumor necrosis factor-mediated signaling pathway. Each is linked with SCUBE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both SCUBE1-to-partner and partner-to-SCUBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of organelle assembly grouped by SCUBE1-low versus SCUBE1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE1→partner) and Y-score (partner→SCUBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Regulation of organelle assembly →	+0.037	+2.338	.007	<.001	2	7
BLOOD_Leukemia	Chaperone-mediated autophagy →	+0.057	+1.041	.002	<.001	3	6
BLOOD_Lymphoma	Positive regulation of tumor necrosis factor-mediated signaling pathway →	+0.111	+0.598	.001	.008	3	5
LUNG_SCLC	Aerobic respiration →	+0.058	+0.874	.001	.003	3	5
SOFT_TISSUE	Negative regulation of organelle assembly →	+0.059	+1.724	.001	<.001	2	6
BLOOD_Leukemia	Mannose metabolic process →	+0.060	+0.834	.001	.008	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,689 associations by consensus.

Regulation of organelle assembly by SCUBE1 expression — LIVER

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