SCUBE1

Across TCGA cell cohorts, SCUBE1 mutation is significantly associated with the RNA expression of many other genes, with 270 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible SCUBE1-associated genes across cancer lineages are LYG1, HRH4, and KRTAP10-1. Each is linked with SCUBE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both SCUBE1-to-partner and partner-to-SCUBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LYG1 grouped by SCUBE1-low versus SCUBE1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE1→partner) and Y-score (partner→SCUBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LYG1 →	+0.918	+3.364	.001	.002	3	3
LUNG_NSCLC_LUSC	HRH4 →	+0.061	+3.584	<.001	.001	3	2
SOFT_TISSUE	KRTAP10-1 →	+0.034	+5.369	.002	.004	3	2
BLOOD_Leukemia	WRAP53 →	+0.607	+3.199	.006	.007	3	2
BLOOD_Leukemia	ODF1 →	+0.052	+2.529	<.001	.004	3	2
BLOOD_Leukemia	SLC35G3 →	+0.032	+2.704	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 270 associations by consensus.

LYG1 by SCUBE1 expression — LARGE_INTESTINE

Explore this box plot interactively →