SCUBE1

Across TCGA patient cohorts, SCUBE1 mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCUBE1-associated genes across cancer lineages are PAI-1, FASN, and FOXO3a. Each is linked with SCUBE1 in more than 4 cancer types. Because this analysis shows association rather than direction, both SCUBE1-to-partner and partner-to-SCUBE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAI-1 grouped by SCUBE1-low versus SCUBE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCUBE1→partner) and Y-score (partner→SCUBE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PAI-1 →	+0.233	+1.584	.033	.017	3	5
UCEC	FASN →	+0.320	+1.289	.011	.023	3	3
UCEC	FOXO3a →	-0.065	-1.385	.043	.044	3	3
UCEC	STAT5a →	+0.314	+2.700	.014	.005	3	3
UCEC	Caspase-7-cleavedD198 →	+0.800	+2.378	<.001	<.001	3	2
UCEC	eIF4E →	+0.134	+1.289	.046	.023	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

PAI-1 by SCUBE1 expression — UCEC

Explore this box plot interactively →