SCUBE1

Across TCGA pan-cancer cohorts, SCUBE1 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated SCUBE1 data layer compared with 22 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher SCUBE1 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated SCUBE1 expression acts as an unfavorable survival marker, although some lineages such as LSCC and CCRCC show a favorable association.

LUAD, LSCC, and CCRCC are the cancer types where SCUBE1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Quartile	All	0.607	1.000	.024	4	view →
LSCC	DFS	Tertile	II,III,IV	1.000	0.498	.040	2	view →
CCRCC	OS	Median	All	1.000	0.687	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

SCUBE1–LUAD (DFS)

Open the LUAD breakdown →