scavenger receptor class B member 1Genealiases: CD36L1 · CLA-1 · CLA1 · HDLCQ6 · HDLQTL6 · SR-BI
Q-omics provides the consensus-scored SCARB1 profile across patient tissues and cancer cell-line models. SCARB1 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, SCARB1 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, SCARB1 protein abundance shows 35,571 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight UVM, KIRC, and LSCC as cancer lineages where SCARB1 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SCARB1 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SCARB1 survival associations across molecular data types. SCARB1 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (6) and mass-spec protein abundance (12). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SCARB1 RNA expression–survival associations across cancer types. High SCARB1 expression shows unfavorable associations in UVM, HNSC, ACC, LUAD and LIHC, but favorable associations in KIRC. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify UVM as the clearest survival context for SCARB1 RNA expression.
This table summarizes SCARB1 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 11. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for SCARB1. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SCARB1 shows higher tumor expression in KIRC, HNSC, KIRP, COAD, STAD and BLCA. The KIRC box plot shows higher SCARB1 RNA expression in tumor versus normal tissue (log2 FC = +4.054, t-test p < 0.001).
This table shows molecular features associated with SCARB1 in patient tissues and cancer cell lines. In patient samples, SCARB1 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, SCARB1 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in PANCREAS, while CRISPR and shRNA rows add functional-dependency signals in CNS and SOFT_TISSUE.
