SCARB1

Across TCGA pan-cancer cohorts, SCARB1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated SCARB1 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher SCARB1 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated SCARB1 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

LSCC, PDAC, and HNSC are the cancer types where SCARB1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Median	III,IV	1.000	0.410	.002	41	view →
PDAC	DFS	Tertile	All	0.693	0.883	.004	28	view →
HNSC	DFS	Median	III,IV	0.461	0.899	.001	25	view →
CCRCC	DFS	Tertile	All	0.661	0.911	.002	10	view →
COAD	DFS	Quartile	III,IV	0.697	1.000	.030	6	view →
LUAD	DFS	Median	All	0.857	0.943	.045	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

SCARB1–LSCC (DFS)

Open the LSCC breakdown →