SCARB1

Across TCGA patient cohorts, SCARB1 mutation is significantly associated with the RNA expression of many other genes, with 2,186 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible SCARB1-associated genes across cancer lineages are LINC00690, RNA5SP204, and MIR4748. Each is linked with SCARB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCARB1-to-partner and partner-to-SCARB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LINC00690 grouped by SCARB1-low versus SCARB1-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB1→partner) and Y-score (partner→SCARB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	LINC00690 →	+0.039	+5.683	.008	.004	3	2
BLCA	RNA5SP204 →	+0.307	+4.859	<.001	.004	3	2
UCEC	MIR4748 →	+0.611	+1.895	<.001	.002	3	2
CESC	MIR4527HG →	+0.113	+3.817	<.001	.009	3	2
LUSC	MIR5692C1 →	+0.548	+5.309	<.001	.003	3	2
UCEC	MIR7976 →	+0.516	+2.646	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,186 associations by consensus.

LINC00690 by SCARB1 expression — BRCA

Explore this box plot interactively →