SCARB1

Across TCGA cell cohorts, SCARB1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,231 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible SCARB1-associated GO terms across cancer lineages are Positive regulation of nitric oxide mediated signal transduction, Recognition of apoptotic cell, and Lipoprotein particle mediated signaling. Each is linked with SCARB1 in more than 19 cancer types. Because this analysis shows association rather than direction, both SCARB1-to-partner and partner-to-SCARB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of nitric oxide mediated signal transduction grouped by SCARB1-low versus SCARB1-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB1→partner) and Y-score (partner→SCARB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Positive regulation of nitric oxide mediated signal transduction →	+1.023	+2.101	.003	<.001	3	20
LUNG_SCLC	Recognition of apoptotic cell →	+0.708	+1.570	<.001	<.001	3	20
BONE	Lipoprotein particle mediated signaling →	+0.304	+1.600	<.001	<.001	3	20
LIVER	Regulation of phosphatidylcholine catabolic process →	+0.414	+2.557	<.001	<.001	3	19
LIVER	High-density lipoprotein particle clearance →	+0.427	+1.913	<.001	<.001	3	19
UPPER_AERODIGESTIVE_TRACT	Phagocytosis, recognition →	+1.159	+1.583	<.001	<.001	3	18

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,231 associations by consensus.

Positive regulation of nitric oxide mediated signal transduction by SCARB1 expression — LUNG_NSCLC_LUSC

Explore this box plot interactively →