SCARB1

Across TCGA cell cohorts, SCARB1 mutation is significantly associated with the RNA expression of many other genes, with 13 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible SCARB1-associated genes across cancer lineages are OPALIN, KIR2DL3, and CLRN2. Each is linked with SCARB1 in more than 1 cancer types. Because this analysis shows association rather than direction, both SCARB1-to-partner and partner-to-SCARB1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OPALIN grouped by SCARB1-low versus SCARB1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (SCARB1→partner) and Y-score (partner→SCARB1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	OPALIN →	+0.072	+4.977	<.001	.007	3	1
SKIN	KIR2DL3 →	+0.006	+4.977	<.001	.007	3	1
SKIN	CLRN2 →	+0.025	+4.977	<.001	.007	3	1
SKIN	OR11H2 →	+0.044	+4.977	<.001	.007	3	1
LARGE_INTESTINE	DEFA4 →	+0.022	+3.700	<.001	.009	3	1
LARGE_INTESTINE	TMEM95 →	+0.014	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

OPALIN by SCARB1 expression — SKIN

Explore this box plot interactively →