secretory carrier membrane protein 2Genealiases: []
Q-omics provides the consensus-scored SCAMP2 profile across patient tissues and cancer cell-line models. SCAMP2 expression is associated with patient survival in 20 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, SCAMP2 is differentially expressed in 13, with the highest sampling consensus in COAD. Additionally, SCAMP2 RNA expression shows 19,654 significant gene co-expression associations, with the highest sampling consensus in ACC. Together, these results highlight KIRC, COAD, and ACC as cancer lineages where SCAMP2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for SCAMP2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes SCAMP2 survival associations across molecular data types. SCAMP2 RNA expression shows survival associations in the most cancer types (20), followed by mutation status (4) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible SCAMP2 RNA expression–survival associations across cancer types. High SCAMP2 expression shows unfavorable associations in BLCA, LAML and LGG, but favorable associations in KIRC, UCEC and MESO. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for SCAMP2 RNA expression.
This table summarizes SCAMP2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 13, while mass-spec protein shows differences in 4. The strongest signals are observed in COAD for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for SCAMP2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. SCAMP2 shows lower tumor expression in COAD and READ and higher tumor expression in LIHC, BLCA, CHOL and STAD. The COAD box plot shows higher SCAMP2 RNA expression in normal versus tumor tissue (log2 FC = −1.095, t-test p < 0.001).
This table shows molecular features associated with SCAMP2 in patient tissues and cancer cell lines. In patient samples, SCAMP2 shows the broadest associations at the RNA and protein expression levels, with ACC recurring as the lineage with the largest associated feature set. In cancer cell lines, SCAMP2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LIVER, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Lymphoma.
