Ras protein specific guanine nucleotide releasing factor 2Genealiases: GRF2 · RAS-GRF2
Q-omics provides the consensus-scored RASGRF2 profile across patient tissues and cancer cell-line models. RASGRF2 expression is associated with patient survival in 24 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, RASGRF2 is differentially expressed in 11, with the highest sampling consensus in KIRP. Additionally, RASGRF2 RNA expression shows 25,279 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRP, and GBM as cancer lineages where RASGRF2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for RASGRF2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes RASGRF2 survival associations across molecular data types. RASGRF2 RNA expression shows survival associations in the most cancer types (24), followed by mutation status (10) and mass-spec protein abundance (6). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible RASGRF2 RNA expression–survival associations across cancer types. High RASGRF2 expression shows unfavorable associations in KIRP, STAD and MESO, but favorable associations in KIRC, LIHC and HNSC. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for RASGRF2 RNA expression.
This table summarizes RASGRF2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 3. The strongest signals are observed in LIHC for RNA and PDAC for protein.
This table ranks reproducible tumor–normal expression differences for RASGRF2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. RASGRF2 shows lower tumor expression in KIRP, THCA, UCEC and BRCA and higher tumor expression in LIHC and HNSC. The KIRP box plot shows higher RASGRF2 RNA expression in normal versus tumor tissue (log2 FC = −1.504, t-test p < 0.001).
This table shows molecular features associated with RASGRF2 in patient tissues and cancer cell lines. In patient samples, RASGRF2 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, RASGRF2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in UPPER_AERODIGESTIVE_TRACT, while CRISPR and shRNA rows add functional-dependency signals in SOFT_TISSUE and LARGE_INTESTINE.
