RASGRF2

Across TCGA cell cohorts, RASGRF2 mutation is significantly associated with the RNA expression of many other genes, with 510 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RASGRF2-associated genes across cancer lineages are MIOX, SLC35G3, and SLC15A5. Each is linked with RASGRF2 in more than 1 cancer types. Because this analysis shows association rather than direction, both RASGRF2-to-partner and partner-to-RASGRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIOX grouped by RASGRF2-low versus RASGRF2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRF2→partner) and Y-score (partner→RASGRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MIOX →	+0.350	+3.212	<.001	.006	3	2
BLOOD_Leukemia	SLC35G3 →	+0.049	+3.289	<.001	.009	3	2
OESOPHAGUS	SLC15A5 →	+0.007	+4.857	<.001	<.001	3	1
OESOPHAGUS	H4C6 →	+0.328	+4.017	<.001	.007	3	1
BLOOD_Lymphoma	OPN1LW →	+0.021	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	SPATA31A6 →	+0.022	+5.643	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 510 associations by consensus.

MIOX by RASGRF2 expression — LARGE_INTESTINE

Explore this box plot interactively →