Q-omics provides the consensus-scored H4C6 profile across patient tissues and cancer cell-line models. H4C6 expression is associated with patient survival in 16 of 34 cancer types, with the highest sampling consensus in THCA. Among the 18 cancer types available for tumor–normal comparison, H4C6 is differentially expressed in 8, with the highest sampling consensus in COAD. Additionally, H4C6 RNA expression shows 10,067 significant gene co-expression associations, with the highest sampling consensus in THYM. Together, these results highlight THCA, COAD, and THYM as cancer lineages where H4C6 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for H4C6 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes H4C6 survival associations across molecular data types. H4C6 RNA expression shows survival associations in the most cancer types (16), followed by mutation status (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible H4C6 RNA expression–survival associations across cancer types. High H4C6 expression shows unfavorable associations in THCA, LGG and BLCA, but favorable associations in STAD, KIRP and ESCA. The THCA Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify THCA as the clearest survival context for H4C6 RNA expression.
This table summarizes H4C6 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 8. The strongest signals are observed in COAD for RNA.
This table ranks reproducible tumor–normal expression differences for H4C6. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. H4C6 shows lower tumor expression in COAD, THCA and READ and higher tumor expression in HNSC, UCEC and STAD. The COAD box plot shows higher H4C6 RNA expression in normal versus tumor tissue (log2 FC = −0.284, t-test p < 0.001).
This table shows molecular features associated with H4C6 in patient tissues and cancer cell lines. In patient samples, H4C6 shows the broadest associations at the RNA and protein expression levels, with THYM recurring as the lineage with the largest associated feature set. In cancer cell lines, H4C6 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in CNS, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
