H4C6

Across TCGA patient cohorts, H4C6 mutation is significantly associated with the RNA expression of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible H4C6-associated genes across cancer lineages are RNU1-105P, DEFB129, and MAGEB10. Each is linked with H4C6 in more than 1 cancer types. Because this analysis shows association rather than direction, both H4C6-to-partner and partner-to-H4C6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU1-105P grouped by H4C6-low versus H4C6-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (H4C6→partner) and Y-score (partner→H4C6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RNU1-105P →	+0.148	+6.000	<.001	<.001	3	2
CESC	DEFB129 →	+0.044	+5.252	<.001	.002	3	1
CESC	MAGEB10 →	+0.099	+3.653	<.001	.009	3	1
CESC	RNU6-211P →	+0.203	+4.757	<.001	.004	3	1
CESC	SNORD56B →	+0.420	+3.760	.001	.007	3	1
CESC	RNU6-796P →	+0.584	+4.966	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

RNU1-105P by H4C6 expression — CESC

Explore this box plot interactively →