RASGRF2

Across TCGA patient cohorts, RASGRF2 mutation is significantly associated with the total protein of many other genes, with 64 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RASGRF2-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and eEF2. Each is linked with RASGRF2 in more than 3 cancer types. Because this analysis shows association rather than direction, both RASGRF2-to-partner and partner-to-RASGRF2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by RASGRF2-low versus RASGRF2-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RASGRF2→partner) and Y-score (partner→RASGRF2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	ASNS →	+0.776	+3.584	<.001	.002	3	4
COAD	Caspase-7-cleavedD198 →	+1.390	+3.321	<.001	.009	3	4
COAD	eEF2 →	+0.366	+1.882	.003	.031	3	3
COAD	TFRC →	+0.583	+2.610	.008	.005	3	3
UCEC	Cyclin-B1 →	+0.628	+2.502	<.001	.001	3	3
COAD	INPP4B →	-0.413	-2.321	.008	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 64 associations by consensus.

ASNS by RASGRF2 expression — COAD

Explore this box plot interactively →