protein phosphatase targeting COQ7Genealiases: TA-PP2C · TAPP2C
Q-omics provides the consensus-scored PPTC7 profile across patient tissues and cancer cell-line models. PPTC7 expression is associated with patient survival in 21 of 34 cancer types, with the highest sampling consensus in UVM. Among the 18 cancer types available for tumor–normal comparison, PPTC7 is differentially expressed in 11, with the highest sampling consensus in THCA. Additionally, PPTC7 RNA expression shows 19,882 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight UVM, and THCA as cancer lineages where PPTC7 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PPTC7 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PPTC7 survival associations across molecular data types. PPTC7 RNA expression shows survival associations in the most cancer types (21), followed by mutation status (2) and mass-spec protein abundance (2). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PPTC7 RNA expression–survival associations across cancer types. High PPTC7 expression shows unfavorable associations in UVM, MESO, PAAD and LUAD, but favorable associations in KIRC and BRCA. The UVM Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p = .002). Together, the overview and detailed table identify UVM as the clearest survival context for PPTC7 RNA expression.
This table summarizes PPTC7 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 11, while mass-spec protein shows differences in 4. The strongest signals are observed in THCA for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for PPTC7. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PPTC7 shows lower tumor expression in THCA, BRCA, BLCA and COAD and higher tumor expression in HNSC and LUSC. The THCA box plot shows higher PPTC7 RNA expression in normal versus tumor tissue (log2 FC = −0.469, t-test p < 0.001).
This table shows molecular features associated with PPTC7 in patient tissues and cancer cell lines. In patient samples, PPTC7 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, PPTC7 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in SKIN, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and BLOOD_Leukemia.
