Across TCGA patient cohorts, PPTC7 mutation is significantly associated with the total protein of many other genes, with 12 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPTC7-associated genes across cancer lineages are EGFR_pY1068, INPP4B, and Notch1. Each is linked with PPTC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPTC7-to-partner and partner-to-PPTC7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPTC7→partner) and Y-score (partner→PPTC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.267	-3.321	.012	.010	3	1
UCEC	INPP4B →	-0.336	-3.321	.014	.010	2	2
UCEC	Notch1 →	+0.174	+2.472	.003	.010	3	1
UCEC	14-3-3_epsilon →	+0.110	+1.700	.008	.044	3	1
UCEC	PCNA →	+0.230	+1.700	.011	.044	3	1
UCEC	Rab25 →	-0.364	-2.999	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

Exploration

PPTC7 survival (RNA) · tumor vs normal (RNA) · all PPTC7 data types