Across TCGA cell cohorts, PPTC7 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PPTC7-associated genes across cancer lineages are ASB17, C12orf40, and MSGN1. Each is linked with PPTC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPTC7-to-partner and partner-to-PPTC7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPTC7→partner) and Y-score (partner→PPTC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	ASB17 →	+0.017	+4.807	<.001	.003	3	1
OVARY	C12orf40 →	+0.011	+4.029	<.001	.009	3	1
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	C10orf53 →	+0.012	+3.632	<.001	.003	3	1
LARGE_INTESTINE	TAFA1 →	+0.276	+5.009	<.001	<.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.177	+4.155	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

PPTC7 survival (RNA) · tumor vs normal (RNA) · all PPTC7 data types