PPTC7

mutation — cross-omics
Cross-omicsMUTATION → RNAPatientPairwise association · TCGA cohorts

Across TCGA patient cohorts, PPTC7 mutation is significantly associated with the RNA expression of many other genes, with 1,190 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PPTC7-associated genes across cancer lineages are RNU6-666P, KRTAP10-10, and LINC01065. Each is linked with PPTC7 in more than 1 cancer types. Because this analysis shows association rather than direction, both PPTC7-to-partner and partner-to-PPTC7 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PPTC7→partner) and Y-score (partner→PPTC7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.
LineagePartner geneX-scoreY-scorep(X)p(Y)Sampling consensusLineage consensus
COADRNU6-666P →+0.986+6.734<.001<.00132
LUADKRTAP10-10 →+0.085+4.554<.001.00932
LUADLINC01065 →+0.084+5.584<.001.00232
LUADPLCE1P1 →+0.171+6.924<.001<.00132
UCECRNU6-296P →+0.135+2.951<.001.00732
LUSCRNU6-1213P →+0.398+7.924<.001.00832
Each partner links to its Q-omics profile. Showing the 6 strongest of 1,190 associations by consensus.

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