Across TCGA pan-cancer cohorts, PPTC7 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of PPTC7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PPTC7 mass-spec protein is repressed in tumor relative to normal tissue. In most cancer types PPTC7 is over-expressed in tumor, although a few such as HNSC and CCRCC show the opposite, repressed pattern.

HNSC, CCRCC, and PDAC are the cancer types where PPTC7 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PPTC7 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	All	−0.392	<.001	7	view →
CCRCC	All	All	−0.136	.006	5	view →
PDAC	All	All	+0.347	.011	4	view →
LSCC	Male	All	−0.123	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: PPTC7 RNA expression & survival · all PPTC7 data types