Q-omics provides the consensus-scored PMM2 profile across patient tissues and cancer cell-line models. PMM2 expression is associated with patient survival in 23 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, PMM2 is differentially expressed in 16, with the highest sampling consensus in KIRC. Additionally, PMM2 protein abundance shows 28,435 significant protein co-abundance associations, with the highest sampling consensus in GBM. Together, these results highlight KIRP, KIRC, and GBM as cancer lineages where PMM2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PMM2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PMM2 survival associations across molecular data types. PMM2 RNA expression shows survival associations in the most cancer types (23), followed by mutation status (1) and mass-spec protein abundance (8). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PMM2 RNA expression–survival associations across cancer types. High PMM2 expression shows unfavorable associations in KIRP, UVM, CESC, LGG, HNSC and PAAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for PMM2 RNA expression.
This table summarizes PMM2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 16, while mass-spec protein shows differences in 10. The strongest signals are observed in KIRC for RNA and CCRCC for protein.
This table ranks reproducible tumor–normal expression differences for PMM2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PMM2 shows higher tumor expression in KIRC, KIRP, BLCA, HNSC, LUAD and BRCA. The KIRC box plot shows higher PMM2 RNA expression in tumor versus normal tissue (log2 FC = +1.110, t-test p < 0.001).
This table shows molecular features associated with PMM2 in patient tissues and cancer cell lines. In patient samples, PMM2 shows the broadest associations at the RNA and protein expression levels, with GBM recurring as the lineage with the largest associated feature set. In cancer cell lines, PMM2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LARGE_INTESTINE, while CRISPR and shRNA rows add functional-dependency signals in PANCREAS and UPPER_AERODIGESTIVE_TRACT.
