PMM2

Across TCGA patient cohorts, PMM2 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMM2-associated genes across cancer lineages are PDK1, AMPK_pT172, and Annexin-1. Each is linked with PMM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMM2-to-partner and partner-to-PMM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDK1 grouped by PMM2-low versus PMM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMM2→partner) and Y-score (partner→PMM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDK1 →	+0.130	+2.820	.022	.035	3	1
UCEC	AMPK_pT172 →	+0.528	+2.183	.014	.035	3	1
UCEC	Annexin-1 →	+0.722	+3.019	.008	.019	3	1
UCEC	TIGAR →	+0.235	+3.348	.003	.005	3	1
UCEC	CDK1 →	-0.183	-3.000	.020	.036	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

PDK1 by PMM2 expression — UCEC

Explore this box plot interactively →