PMM2

Across TCGA patient cohorts, PMM2 mutation is significantly associated with the RNA expression of many other genes, with 120 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PMM2-associated genes across cancer lineages are SNORD116-22, RNU6-225P, and LINC01869. Each is linked with PMM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PMM2-to-partner and partner-to-PMM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SNORD116-22 grouped by PMM2-low versus PMM2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PMM2→partner) and Y-score (partner→PMM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	SNORD116-22 →	+0.808	+5.362	<.001	.005	3	2
BLCA	RNU6-225P →	+0.352	+7.640	<.001	.009	3	1
UCEC	LINC01869 →	+0.572	+3.345	<.001	.005	3	1
UCEC	PHLDA2 →	+1.327	+3.595	.001	.001	3	1
HNSC	TSPY7P →	+0.039	+7.954	<.001	.008	3	1
HNSC	RNA5SP166 →	+0.298	+7.954	<.001	.008	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 120 associations by consensus.

SNORD116-22 by PMM2 expression — SKCM

Explore this box plot interactively →