PMM2

Across TCGA cell cohorts, PMM2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,974 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible PMM2-associated GO terms across cancer lineages are Symbiont-mediated disruption of host cell PML body, Cytosol to Golgi apparatus transport, and SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition. Each is linked with PMM2 in more than 13 cancer types. Because this analysis shows association rather than direction, both PMM2-to-partner and partner-to-PMM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Symbiont-mediated disruption of host cell PML body grouped by PMM2-low versus PMM2-high in BREAST.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PMM2→partner) and Y-score (partner→PMM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BREAST	Symbiont-mediated disruption of host cell PML body →	+0.118	+0.863	<.001	<.001	3	14
OESOPHAGUS	Cytosol to Golgi apparatus transport →	+0.104	+0.714	.003	.002	2	10
LIVER	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition →	+0.132	+0.667	.002	.002	2	10
BREAST	Negative regulation of nodal signaling pathway →	+0.195	+0.824	.001	.001	2	9
SKIN	Transcription by RNA polymerase I →	+0.107	+0.522	<.001	<.001	3	8
LIVER	Telomerase RNA stabilization →	+0.116	+0.671	.004	.001	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,974 associations by consensus.

Symbiont-mediated disruption of host cell PML body by PMM2 expression — BREAST

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