pellino E3 ubiquitin protein ligase family member 2Genealiases: []
Q-omics provides the consensus-scored PELI2 profile across patient tissues and cancer cell-line models. PELI2 expression is associated with patient survival in 25 of 34 cancer types, with the highest sampling consensus in KIRC. Among the 18 cancer types available for tumor–normal comparison, PELI2 is differentially expressed in 14, with the highest sampling consensus in KIRC. Additionally, PELI2 RNA expression shows 19,245 significant gene co-expression associations, with the highest sampling consensus in UVM. Together, these results highlight KIRC, and UVM as cancer lineages where PELI2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for PELI2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes PELI2 survival associations across molecular data types. PELI2 RNA expression shows survival associations in the most cancer types (25), followed by mutation status (4) and mass-spec protein abundance (3). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible PELI2 RNA expression–survival associations across cancer types. High PELI2 expression shows unfavorable associations in KICH, but favorable associations in KIRC, LGG, LUSC, SCLC and BRCA. The KIRC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRC as the clearest survival context for PELI2 RNA expression.
This table summarizes PELI2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 14, while mass-spec protein shows differences in 6. The strongest signals are observed in KIRC for RNA and HNSC for protein.
This table ranks reproducible tumor–normal expression differences for PELI2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. PELI2 shows lower tumor expression in KIRC, THCA, KICH, BLCA, COAD and KIRP. The KIRC box plot shows higher PELI2 RNA expression in normal versus tumor tissue (log2 FC = −1.372, t-test p < 0.001).
This table shows molecular features associated with PELI2 in patient tissues and cancer cell lines. In patient samples, PELI2 shows the broadest associations at the RNA and protein expression levels, with UVM recurring as the lineage with the largest associated feature set. In cancer cell lines, PELI2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in KIDNEY, while CRISPR and shRNA rows add functional-dependency signals in CNS and BLOOD_Leukemia.
