PELI2

Across TCGA cell cohorts, PELI2 mutation is significantly associated with the mutation status of many other genes, with 2,982 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PELI2-associated genes across cancer lineages are CHRNE, DLGAP5, and SIN3A. Each is linked with PELI2 in more than 2 cancer types. Because this analysis shows association rather than direction, both PELI2-to-partner and partner-to-PELI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHRNE grouped by PELI2-low versus PELI2-high in OVARY.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PELI2→partner) and Y-score (partner→PELI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OVARY	CHRNE →	+5.415	+5.415	.004	.004	1	3
OVARY	DLGAP5 →	+5.415	+5.415	.004	.004	1	3
CNS	SIN3A →	+5.044	+5.614	.003	.003	1	3
LARGE_INTESTINE	PAXIP1 →	+2.289	+3.182	.008	.008	1	3
LARGE_INTESTINE	TDRD10 →	+4.781	+5.536	<.001	<.001	1	3
LARGE_INTESTINE	DDX53 →	+5.781	+5.781	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,982 associations by consensus.

CHRNE by PELI2 expression — OVARY

Explore this box plot interactively →