PELI2

Across TCGA cell cohorts, PELI2 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PELI2-associated genes across cancer lineages are UBE2QL1, CFHR2, and MS4A10. Each is linked with PELI2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PELI2-to-partner and partner-to-PELI2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, UBE2QL1 grouped by PELI2-low versus PELI2-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PELI2→partner) and Y-score (partner→PELI2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	UBE2QL1 →	+0.258	+3.766	<.001	.004	3	1
LARGE_INTESTINE	CFHR2 →	+0.038	+4.022	<.001	.006	3	1
OVARY	MS4A10 →	+0.013	+5.196	<.001	.005	3	1
CNS	HES3 →	+0.044	+5.321	<.001	.005	3	1
CNS	FGF3 →	+0.081	+4.981	<.001	.008	3	1
BLOOD_Leukemia	C1QTNF8 →	+0.046	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

UBE2QL1 by PELI2 expression — LARGE_INTESTINE

Explore this box plot interactively →