Q-omics provides the consensus-scored OTX2 profile across patient tissues and cancer cell-line models. OTX2 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in KIRP. Among the 18 cancer types available for tumor–normal comparison, OTX2 is differentially expressed in 4, with the highest sampling consensus in LUSC. Additionally, OTX2 RNA expression shows 6,387 significant gene co-expression associations, with the highest sampling consensus in TGCT. Together, these results highlight KIRP, LUSC, and TGCT as cancer lineages where OTX2 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for OTX2 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes OTX2 survival associations across molecular data types. OTX2 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (7). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible OTX2 RNA expression–survival associations across cancer types. High OTX2 expression shows unfavorable associations in KIRP, READ, LGG, CHOL, KIRC and COAD. The KIRP Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify KIRP as the clearest survival context for OTX2 RNA expression.
This table summarizes OTX2 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 4. The strongest signals are observed in LUSC for RNA.
This table ranks reproducible tumor–normal expression differences for OTX2. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. OTX2 shows lower tumor expression in KIRC and THCA and higher tumor expression in LUSC and LUAD. The LUSC box plot shows higher OTX2 RNA expression in tumor versus normal tissue (log2 FC = +0.350, t-test p = .001).
This table shows molecular features associated with OTX2 in patient tissues and cancer cell lines. In patient samples, OTX2 shows the broadest associations at the RNA and protein expression levels, with TGCT recurring as the lineage with the largest associated feature set. In cancer cell lines, OTX2 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in BONE, while CRISPR and shRNA rows add functional-dependency signals in LARGE_INTESTINE and LUNG_NSCLC_LUAD.
