OTX2

Across TCGA cell cohorts, OTX2 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible OTX2-associated genes across cancer lineages are OR6V1, PRSS54, and C1orf87. Each is linked with OTX2 in more than 1 cancer types. Because this analysis shows association rather than direction, both OTX2-to-partner and partner-to-OTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR6V1 grouped by OTX2-low versus OTX2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX2→partner) and Y-score (partner→OTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR6V1 →	+0.010	+3.189	.002	.007	3	2
BLOOD_Lymphoma	PRSS54 →	+0.046	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	C1orf87 →	+0.021	+4.867	.008	.009	3	1
BLOOD_Lymphoma	S100A7A →	+0.056	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	IFNL3 →	+0.100	+5.209	.001	.005	3	1
CNS	KNG1 →	+0.018	+4.315	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

OR6V1 by OTX2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →