OTX2

Across TCGA pan-cancer cohorts, OTX2 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of OTX2’s most consistent transcriptional readouts.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where OTX2 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types OTX2 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LUSC, LUAD, and KIRC are the cancer types where OTX2 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in OTX2 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUSC	All	All	+0.350	.001	2	view →
LUAD	All	II,III,IV	+0.008	.014	2	view →
KIRC	Male	II,III,IV	−0.006	.032	2	view →
THCA	All	All	−0.004	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

OTX2–LUSC

Open the LUSC breakdown →