OTX2

Across TCGA cell cohorts, OTX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,026 significant associations in total. BONE shows the largest number of these associations.

The most reproducible OTX2-associated GO terms across cancer lineages are DNA-templated transcription initiation, Negative regulation of mRNA catabolic process, and Regulation of cytoplasmic translation. Each is linked with OTX2 in more than 7 cancer types. Because this analysis shows association rather than direction, both OTX2-to-partner and partner-to-OTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA-templated transcription initiation grouped by OTX2-low versus OTX2-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX2→partner) and Y-score (partner→OTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	DNA-templated transcription initiation →	+0.078	+3.462	.002	.003	3	8
BONE	Negative regulation of mRNA catabolic process →	+0.064	+4.558	.001	<.001	3	7
BONE	Regulation of cytoplasmic translation →	+0.131	+4.611	<.001	<.001	3	7
BONE	Granzyme-mediated apoptotic signaling pathway →	+0.097	+4.346	.001	<.001	3	6
CNS	Response to macrophage colony-stimulating factor →	-0.495	-2.053	.004	.007	3	6
BONE	Epigenetic regulation of gene expression →	+0.082	+3.791	.001	.007	2	7

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,026 associations by consensus.

DNA-templated transcription initiation by OTX2 expression — BONE

Explore this box plot interactively →