OTX2

Across TCGA patient cohorts, OTX2 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTX2-associated genes across cancer lineages are ERK2, Cyclin-E2, and eEF2. Each is linked with OTX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTX2-to-partner and partner-to-OTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by OTX2-low versus OTX2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX2→partner) and Y-score (partner→OTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.199	+2.999	.014	.035	3	3
UCEC	Cyclin-E2 →	+0.170	+1.594	.017	.042	3	3
UCEC	eEF2 →	+0.408	+2.906	.007	.001	3	2
UCEC	JNK2 →	+0.245	+2.222	.003	.011	3	2
UCEC	MEK1 →	+0.345	+2.321	.026	.034	3	2
UCEC	Src_pY527 →	-0.447	-1.700	.014	.044	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

ERK2 by OTX2 expression — UCEC

Explore this box plot interactively →