OTX2

Across TCGA patient cohorts, OTX2 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,024 significant associations in total. HNSC shows the largest number of these associations.

The most reproducible OTX2-associated GO terms across cancer lineages are Positive regulation of mitotic cell cycle phase transition, Positive regulation of mitotic cell cycle, and Protein stabilization. Each is linked with OTX2 in more than 15 cancer types. Because this analysis shows association rather than direction, both OTX2-to-partner and partner-to-OTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of mitotic cell cycle phase transition grouped by OTX2-low versus OTX2-high in STAD.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX2→partner) and Y-score (partner→OTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	Positive regulation of mitotic cell cycle phase transition →	+0.052	+0.134	<.001	<.001	3	15
ESCA	Positive regulation of mitotic cell cycle →	+0.069	+0.289	<.001	.005	2	16
STAD	Protein stabilization →	+0.084	+0.151	<.001	.001	3	15
STAD	Nucleobase-containing compound transport →	+0.095	+0.192	<.001	<.001	3	14
ESCA	Positive regulation of cell cycle phase transition →	+0.063	+0.312	<.001	.009	1	16
STAD	DNA strand elongation →	+0.091	+0.190	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,024 associations by consensus.

Positive regulation of mitotic cell cycle phase transition by OTX2 expression — STAD

Explore this box plot interactively →