OTX2

Across TCGA patient cohorts, OTX2 mutation is significantly associated with the RNA expression of many other genes, with 2,824 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible OTX2-associated genes across cancer lineages are MIR7845, RNU6-328P, and PSMD9. Each is linked with OTX2 in more than 2 cancer types. Because this analysis shows association rather than direction, both OTX2-to-partner and partner-to-OTX2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR7845 grouped by OTX2-low versus OTX2-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (OTX2→partner) and Y-score (partner→OTX2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MIR7845 →	+0.176	+2.333	<.001	.002	3	3
BLCA	RNU6-328P →	+0.258	+4.618	<.001	.005	3	2
UCEC	PSMD9 →	+0.359	+2.502	.003	.009	3	2
UCEC	RAB35 →	+0.365	+1.925	.005	.005	3	2
SKCM	FANCE →	+0.465	+1.925	.006	.009	3	2
SKCM	EMC6 →	+0.526	+3.709	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,824 associations by consensus.

MIR7845 by OTX2 expression — SKCM

Explore this box plot interactively →