neurexophilin and PC-esterase domain family member 4Genealiases: C11orf33 · FAM55D
Q-omics provides the consensus-scored NXPE4 profile across patient tissues and cancer cell-line models. NXPE4 expression is associated with patient survival in 19 of 34 cancer types, with the highest sampling consensus in HNSC. Among the 18 cancer types available for tumor–normal comparison, NXPE4 is differentially expressed in 10, with the highest sampling consensus in COAD. Additionally, NXPE4 RNA expression shows 13,405 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight HNSC, COAD, and LSCC as cancer lineages where NXPE4 shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for NXPE4 — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes NXPE4 survival associations across molecular data types. NXPE4 RNA expression shows survival associations in the most cancer types (19), followed by mutation status (8) and mass-spec protein abundance (1). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible NXPE4 RNA expression–survival associations across cancer types. High NXPE4 expression shows favorable associations in HNSC, SKCM, KIRP, COAD, UCEC and READ. The HNSC Kaplan–Meier curve shows clear separation, with the low-expression group declining faster, consistent with the favorable association (log-rank p < 0.001). Together, the overview and detailed table identify HNSC as the clearest survival context for NXPE4 RNA expression.
This table summarizes NXPE4 tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 10, while mass-spec protein shows differences in 1. The strongest signals are observed in COAD for RNA and COAD for protein.
This table ranks reproducible tumor–normal expression differences for NXPE4. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. NXPE4 shows lower tumor expression in COAD, KICH, BRCA, READ, HNSC and STAD. The COAD box plot shows higher NXPE4 RNA expression in normal versus tumor tissue (log2 FC = −4.232, t-test p < 0.001).
This table shows molecular features associated with NXPE4 in patient tissues and cancer cell lines. In patient samples, NXPE4 shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set. In cancer cell lines, NXPE4 RNA and mutation anchors are most strongly linked to RNA-expression features, especially in LUNG_NSCLC_LUAD, while CRISPR and shRNA rows add functional-dependency signals in UPPER_AERODIGESTIVE_TRACT and LARGE_INTESTINE.
